724703 and no. The similarity between Goyet Q116-1 and Goyet Q376-3 and the Fournol cluster is also observed at the mtDNA level, with both groups including individuals who carried mtDNA haplogroup M, which has not been found in European individuals from after the LGM24 (Extended Data Figs. "We find that individuals associated with a later culture, the Epigravettian, are genetically distinct from the area's previous inhabitants," says co-author He Yu. It will provide you with confidence and methodology for demonstrating the required skills appropriately. CNRS, MNHN, Universit de Paris Cit, Muse de lHomme, Paris, France, PALEVOPRIM Lab UMR 7262 CNRS-INEE, University of Poitiers, Poitiers, France, Centre de Valorisation des Collections Scientifiques, Universit de Poitiers, Mignaloux Beauvoir, France, Muses de PoitiersVille de Poitiers, Poitiers, France, Departamento de Geologa, Facultad de Ciencia y Tecnologa, Universidad del Pas Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain, Sociedad de Ciencias Aranzadi, Donostia-San Sebastian, Spain, Centro UCM-ISCIII de Investigacin sobre Evolucin y Comportamiento Humanos, Madrid, Spain, Institute of Archaeology, University of Rzeszw, Rzeszw, Poland, Foundation for Rzeszw Archaeological Centre, Rzeszw, Poland, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, Harvard Medical School, Boston, MA, USA, Groninger Instituut voor Archeologie, Groningen University, Groningen, The Netherlands, Institute of Archaeology and Ethnology, Polish Academy of Science, Pozna, Poland, Institute of History, Archaeology and Ethnography, Dushanbe, Tajikistan, ArchaeoZOOlogy in Siberia and Central AsiaZooSCAn, CNRSIAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia, Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia, Grupo de I+D+i EVOADAPTA (Evolucin Humana y Adaptaciones durante la Prehistoria) Departamento de Ciencias Histricas, Universidad de Cantabria, Santander, Spain, Borja Gonzlez-Rabanal,Ana B. Marn-Arroyo&Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistricas de Cantabria (IIIPC), Universidad de Cantabria-Gobierno de Cantabria-Banco Santander, Santander, Spain, Departamento de Biologa de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain, Quaternary Environments and Humans, OD Earth and History of Life, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Caroline Polet,Ivan Jadin&Sbastien Villotte, Muses Royaux dArt et dHistoire, Bruxelles, Belgium, Institute of Historical Research, University of Girona, Catalonia, Spain, Joaquim Soler,Neus Coromina&Isaac Ruf, INRAP/UMR 8215 Trajectoires 21, Paris, France, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA, Department of Anthropology, University of New Mexico, Albuquerque, NM, USA, GoArchPal-GoArchon, Viville sous-les-Cotes, France, Archologie & Mnzkabinett, Universalmuseum Joanneum, Graz, Austria, Museum Das Dorf des Welan, Wllersdorf-Steinabrckl, Austria, Department of Humanities, University of Ferrara, Ferrara, Italy, National Museum of Antiquities, Leiden, The Netherlands, Faculty of Archaeology, Leiden University, Leiden, The Netherlands, Biogeology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Unit de Recherches Art, Archologie Patrimoine, Universit de Lige, Lige, Belgium, I.U. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. Quat. Echinacea. 1a, and the y-axes report time in thousand years before present (kBP). 27, 18011810.e10 (2017). Fu, Q. et al. Leveraging the substantially increased sample size, we investigated genetically distinct hunter-gatherer groups for allele frequencies at selected loci that are known to be associated with specific phenotypic traits in present-day Europeans (Fig. There is no biographical data to display. In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. The Sidelkino ancestry also emerged around 14ka with its first direct evidence in eastern Europe43 dated to 13ka. Lazaridis, I. et al. An early modern human from Romania with a recent Neanderthal ancestor. "Ice Age survivors." Article Nature 551, 368372 (2017). Prfer, K. et al. Top 10 Data Science Influencers to Follow on YouTube in 2023 Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Last Name Huang #8. She is also a popular YouTuber with over 60k subscribers. has received funding from the Van de Kamp fonds. 211 and Supplementary Table 1). Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Both of these books focus on the science and math behind data mining. Our limited-time offer covers individual course purchases only. We tested the affinity of Tutkaul 1 to worldwide ancient and modern populations relative to AG3. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. 7, eabd6535 (2021). Curr. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Weissensteiner, H. et al. Packed with 10 mock-up interviews with real life questions, this course provides you with the expert walkthrough you need to feel at ease showing your SQL knowledge, along with helpful tips on how to and recover from mistakes quickly and gracefully, prepare for follow-up questions, and remain calmduring the interview. Fifth, the Oberkassel ancestry in western and central Europe and the Sidelkino ancestry in eastern Europe remained largely isolated for almost 6,000 years until genetic interactions were first observedaround 8ka in northeastern Germany, possibly associated with cultural exchanges along the Baltics49 and around 7.5ka in the upper Volga region, possibly linked to the spread of pottery in the region50. Brunel, S. et al. Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). Highly recommended for not only people preparing for interviews but for people that just want to improve their coding skills. Saag, L. et al. We report 47 new radiocarbon dates performed on skeletal elements of 40 individuals by the Curt-Engelhorn-Zentrum Archaeometrie in Mannheim (MAMS, n=29), Center for Isotope Research, University of Groningen (GrA and GrM, n=5), University of Aarhus (AAR, n=3), Beta Analytics (Beta, n=2), Zrich (ETH, n=3), International Chemical Analysis (ICA, n=2), Natural History Museum in Paris (Echo Lab, n=1) and Vilnius (FTMC, n=2) (Supplementary Data 1.A). Tina Huang. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. October 28 Actress #31. 39, msac017 (2022). Enjoy maximum flexibility and forget about cramming against the clock. The formation of human populations in South and Central Asia. Protoc. Quat. Ive always liked the idea of using data to make predictions. I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. A genome sequence from a modern human skull over 45,000 years old from Zlat k in Czechia. The ancient human specimens analysed in this work derive from multiple scientific collaborations. Brace, S. et al. BMC Res. Jobs People Learning Dismiss Dismiss. The error bar shows the s.e.m. In panel b, the colour code does not imply archaeological similarities. Extensive farming in Estonia started through a sex-biased migration from the steppe. Proc. HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. The triangles show the average calibrated dates of the tested groups and the dots show the estimated admixture dates with the software DATES105 using Oberkassel (red dots) or Villabruna (blue dots) clusters as one source and ANE-related individuals as the other source population. This broadly distributed ancestry (the Oberkassel cluster (also known as WHG)) is most closely related to an Epigravettian-associated individual from northwestern Italy, suggesting that its expansion into continental Europe might have started from the westand not the eastside of the Alps. SDS 563: How to Rock at Data Science with Tina Huang The length of the colour bar shows the proportion of each ancestry. How to Rock at Data Science with Tina Huang Jon Krohn Finally, unsupervised clustering and more complex techniques, such as deep learning, also have their place. Nat. Were dedicated to providing you the best ofNews, with a focus on dependability andBusiness. Dabney, J. et al. Opin. Tina Huang - Instructor | 365 Data Science Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. The more information you have the more data you need to analyze and make your predictions. The code for the newly developed ROH based contamination estimate method is available at https://github.com/hyl317/hapROH. Jones, E. R. et al. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. Check out my courses where we apply scientifically backed learning techniques to accomplish our goals. Individuals and groups are plotted with the same colours and symbols as in Fig. tina huang data science Explained in Instagram Photos Her motto to live by is "Always minimize effort and maximize outcome!". This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. Hi, my name is Tina and I'm a data scientist at a FAANG company. Most Popular #86731. b, Calibrated radiocarbon dates of individuals plotted in a. To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Nucleic Acids Res. In this case, the data is being loaded from the MySQL database. Data Engineer Cover Letter Sample and Template. Fab Business Solutionsis a ProfessionalNewsPlatform. The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. Tina has 11 jobs listed on their profile. We further modelled the genetic profile of pre-LGM individuals with qpGraph (Supplementary Information, section10 and Supplementary Figs. Save my name, email, and website in this browser for the next time I comment. F4-statistics further support this view, revealing that Le Piage II is more closely related to the Fournol clusterthan the Vstonice cluster (f4(Mbuti, Le Piage II; Vstonice, Fournol 85)0, Z=6.58). The course you are purchasing is still hosted by 365 Data Science and comes with most of the perks of our dedicated platform resume builder, user dashboard, Q&A hub, and more. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. We also genotyped a selection of previously published individuals with the same approach (Supplementary Data 1.G)2,4,30,74,75,76,77,78. The Gravettian from a palaeodemographic point of view. Biol. Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Adv. Content on this website is for information only. Check out Why is Burnout So Common in Tech? Adv. SQL for Data Science Interviews . Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Now we have Areej AbuAli, an SEO manager and the founder of Women in Tech SEO. Everything you need to know is included in the course. You also get a peek at Tina's Resume, so I don't think you want to miss out on that. 1517). Ruiz-Redondo, A. et al. Tina Huang is one of the top three students to show up to compete. The bivariate plots show the expansion of Oberkassel and Sidelkino ancestries through time in two European areas (longitude below and above 30 degrees). Tina Huang (@hellotinah) / Twitter Check it out! Data warehousing is a field where you often have to deal with a lot of raw data. 38. Article Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). Nat. The data generated in this study enabled us to investigate genomic transformations of and interactions between Eurasian hunter-gatherers at high resolution (Extended Data Fig. Ancient admixture in human history. Previously worked at Goldman Sachs and the Ontario Institute for . 1 and 2). Unlike setting up a Premium subscription to our platform, for which you would be billed monthly or annually, acquiring individual courses requires a one-time payment only. What is a Pie Chart in Data Visualization? & Hlie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from 13C and 18O of large mammal remains. Claim Author Page. The Kostenki genetic signature (related to the Kostenki 14 genome, and hereafter referred to as the Kostenkicluster or ancestry) contributed to the later Vstonice genetic cluster(hereafter,Vstonice cluster or ancestry), named after the Doln Vstonice site in Czechia4. If youd like to learn more about data science, transitioning into computer science, and software engineering, you can also subscribe to my YouTube channel. Tina Huang hellotinah@gmail.com | 123-456-7890 | 1 BeepbeepBoop St. Philadelphia, PA 19104 EDUCATION AND HONORS University of The dates were calibrated using OxCal 4.452 with calibration curve IntCal20 at 95.4% probability53 and when multiple dates were available for the same individual we used the function R_Combine to combine them52. ather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. 16, e2003703 (2018). Villalba-Mouco, V. et al. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. Cuando se ampla, se proporciona una lista de opciones de bsqueda para que los resultados coincidan con la seleccin actual. Showcase your skills and bolster your data science credentials. Courses hellotinah c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). J. Quat. 6 West Eurasian PCA showing the genetic positioning of post-LGM hunter-gatherers. The analysed individuals span from the Upper Palaeolithic to the Neolithic. These models are easy to implement as well as really helpful in deciding what to build and how much to invest in it. The 10 mock interviews provide a great detailed approach to solving any SQL questions. Catalano, G. et al. Teaching Assistant. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. Nature 534, 200205 (2016). Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic. Is There a Role for Renal Denervation in the Treatment of Hypertension After another MinElute purification, the product was quantified using the Agilent 2100 Bioanalyzer DNA 1000 chip. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. This is . Science 366, 708714 (2019). Nature 524, 216219 (2015). Extended Data Fig. Tina K. Sorensen. In particular, the model achieves 96.21% for the validation and 96.47% for testing using the news aggregator data. Nat. Us Too. B 370, 20130624 (2015). Our analyses demonstrate that the Fournol cluster is a better source for Magdalenian-associated genomes than Goyet Q116-1. Bold letters refer to (a) mtDNA and (b) Ychr haplogroups, whose boxes are coloured according to the legend in Extended Data Fig. Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. PubMed Charlton, S. et al. Theyre both important sub-tasks for data scientists to master, but big data data warehousing and data science are only two components of the larger data science endeavor. The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. This figure shows (a) the distribution of and interaction between hunter-gatherer genetic ancestries and (b) a simplified schematic representation of major chrono-cultural subdivisions of the European Upper Palaeolithic (green blocks) followed by a grouped Mesolithic to Neolithic block (in gray). We only plotted groups with more than two individuals and, for this reason, individuals from the GoyetQ116-1 cluster are included here into the Fournol cluster. tina huang data science Explained in Instagram Photos. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. Nat. Evol. In other cases, you may have to create a more complex database structure (such as SQLite). Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. Article In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. Publicacin de Tina Llorca CPA, CWP, CEPP, CIS, MDRT Join now Sign in . wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. Ecol. thua808@aucklanduni.ac.nz. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Nat. We also compared its affinity to El Mirn (northern Spain), the oldest Magdalenian-associated individual sequenced to date (19ka). Google Scholar. Ecol. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. Trans. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). A series of f4-symmetry statistics confirm that all the Epigravettian-associated individuals are cladal, and do not share excess affinity with any local (Paglicci 12) or non-local preceding ancestries (Goyet Q116-1, Kostenki 14, Malta 1 or Vstonice) (Supplementary Data 2.F). Proc. 8 Effective tina huang data science Elevator Pitches 71, 465492 (2015). The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. 116, 105100 (2020). L. Sineo, M.L. She then pursued a Masters . Mayra Alexandra Castrosqui - Quantitative Analyst - LinkedIn F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). Notes 9, 88 (2016).